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GRT Task 3
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BIOCHEMISTRY
Competency 208.5.3: Protein Function—Myoglobin and Hemoglobin – The graduate constructs models of various states of hemoglobin, demonstrates how changes in the usual configuration of hemoglobin can lead to molecular disease, and distinguishes between the chemical structure and function of hemoglobin and myoglobin.
Introduction:
Hemoglobin is an essential protein necessary for the transport of oxygen in the body. Biochemists study the molecular activities necessary for the exchange and transport of oxygen between the body cells and lungs.
Requirements:
Design either a multimedia presentation (e.g., PowerPoint, Keynote) or a report (e.g., Microsoft Word) to teach laboratory technology students about hemoglobin and genetically transmitted molecular disease by doing the following:
Note: Please save submission documents as *.ppt, *.pptx (PowerPoint), *.key (Keynote), *.doc, *.docx (Word) or *.pdf (Portable Document Format) files. If you are using Google Presentations or Documents, you must save the file in *.pdf format and upload the *.pdf file.
A. Create an original model of hemoglobin that shows how oxygen is carried by the molecule.
1. Label the following components in your model:
• subunits
• heme groups
• iron atoms
• oxygen molecules
Note: You can use ribbon, pipe cleaners, or similar materials in your model.
Note: Take a picture of your completed model as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.
2. Explain three major differences between the oxygenated and deoxygenated states of hemoglobin.
3. Explain how pH impacts the binding and release of oxygen by hemoglobin.
a. Create an original graph that demonstrates the relationship between hemoglobin’s oxygen binding and oxygen concentration at different pH levels.
4. Create an original diagram that compares the biochemical (protein) structure of hemoglobin to myoglobin.
a. Label each of the following components in the diagram from part A4 to show the comparison:
• subunits
• heme groups
• iron atoms
• oxygen molecules
Note: Take a picture of your completed diagrams as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.
B. Demonstrate your understanding of sickle cell anemia by doing the following:
1. Create an original diagram that demonstrates the molecular difference (amino acid change) between normal and sickle forms of hemoglobin.
Note: Take a picture of your completed diagram as evidence that you created it. You can include the picture as part of your presentation or report, or you can upload it in Taskstream as a separate attachment.
2. Create an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level.
Note: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.
3. Compare how diseased cells differ from normal red blood cells in their capacity to transport and deliver oxygen.
4. Explain the molecular inheritance of sickle cell anemia by doing the following:
a. Identify the type of inheritance seen in sickle cell anemia.
b. Describe the outcomes for the offspring of two carrier parents (genotype and phenotype and percentages of each).
c. Create a diagram, or series of simple diagrams, that demonstrates of how sickle cell genes are inherited (e.g., pedigree charts, Punnett squares).
Note: Take a picture of your completed diagram. You can include the picture as part of your presentation or report, or you can upload it in TaskStream as a separate attachment.
C. When you use sources, include all in-text citations and references in APA format.
Note: For definitions of terms commonly used in the rubric, see the attached Rubric Terms.
Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.
Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources, even if cited correctly. For tips on using APA style, please refer to the APA Handout web link included in the General Instructions section.
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